Insecticide MOA Webinar → Bulletin Update
Prepared by: Rich Braman, UGA Cooperative Extension / Center for Urban Agriculture
For: Dr. Dan Suiter & Dr. Michael Scharf — Writing reference
Source: GTBOP_ProseTranscript_2017-10-18_InsecticideMOA.md
Purpose
This guide maps each proposed bulletin section (from the Bulletin Draft Outline) to the specific section of the prose transcript and the approximate video timestamps where that content appears. Use this to:
- Quickly locate Mike’s exact wording on any topic
- Verify that bulletin content stays faithful to the source
- Find passages to quote, paraphrase, or expand upon
- Identify where Mike’s Q&A responses add content beyond his prepared slides
How to Use
The Transcript Section column tells you which heading to search for in the prose transcript file. The Video Timestamp column gives the approximate time range if you need to re-watch the original recording. The Content Type column indicates whether the material comes from the prepared presentation or from the Q&A discussion with Dan.
Mapping Table
| Bulletin Section | Transcript Section | Video Timestamp | Content Type | Notes |
|---|---|---|---|---|
| PART I: Why Understanding MOA Matters | ||||
| 1.1 Safety & non-target toxicity | ”Why Understanding Mode of Action Matters” + “Understanding LD50” | ~2:55–5:35 + ~19:50–22:45 | Presentation | Safety framing at start; LD50 details in classification section |
| 1.2 Interpreting trade literature | ”Why Understanding Mode of Action Matters” | ~3:30–3:45 | Presentation | Brief mention — one sentence |
| 1.3 Pollinator protection | ”Why Understanding Mode of Action Matters” | ~3:36–4:00 | Presentation | Brief but important; expand with current info |
| 1.4 Resistance management | ”Resistance” + multiple Q&A sections | ~54:20–56:30 + ~57:55–59:50 | Both | Extensive Q&A content supplements presentation |
| 1.5 Product sustainability & communication | ”Why Understanding Mode of Action Matters” + Q&A on new AIs | ~4:15–5:50 + ~59:55–1:01:10 | Both | Economics from Q&A adds industry context |
| PART II: Insect Physiology | ||||
| 2.1 Overview of relevant physiology | ”Insect Physiology Overview” (all subsections) | ~8:25–13:58 | Presentation | Compressed physiology primer |
| 2.2 How the nervous system works | ”How the Nervous System Works” | ~23:45–26:45 | Presentation | Electrical + chemical transmission; synapse explanation |
| 2.3 Neurophysiology demonstration | ”Neurophysiology in the Lab” | ~26:50–28:40 | Presentation | Cockroach nerve cord + fipronil electrophysiology |
| PART III: Classification Fundamentals | ||||
| 3.1 Chemical structure & classification | ”Insecticide Classification and Target Sites” | ~14:00–15:15 | Presentation | Structure → function → target site relationship |
| 3.2 Key and lock analogy | ”The Key and Lock Analogy” | ~16:00–17:50 | Presentation | Key-lock + molecular docking + drug design parallel |
| 3.3 Four basic modes of action | ”Four Basic Modes of Action” | ~17:50–19:35 | Presentation | Stimulation, blockage, modulation, inhibition |
| 3.4 Understanding LD50 | ”Understanding LD50” | ~19:40–22:45 | Presentation | Inverse relationship; mammalian safety; billionths ratio |
| PART IV: Neurotoxic Insecticides | ||||
| 4.1 Target site roadmap | ”Target Site Roadmap” | ~28:40–32:15 | Presentation | Visual overview of all target site locations on neuron |
| 4.2 Sodium channel insecticides | ”Classification 1: Sodium Channel Insecticides” + Q&A repellency | ~32:20–34:10 + ~1:04:55–1:05:15 | Both | Pyrethroids/pyrethrins, indoxacarb, metaflumizone; “pepper spray” from Q&A |
| 4.3 Chloride channel insecticides | ”Classification 2: Chloride Channel Insecticides” | ~34:10–36:20 | Presentation | Fipronil, isoxazolines, abamectin; opposite effects at same site |
| 4.4 Acetylcholine receptor insecticides | ”Classification 3: Acetylcholine Receptor Insecticides” + Q&A nicotinoid terminology | ~36:20–37:30 + ~1:02:40–1:03:40 | Both | Neonics, sulfoximines, spinosyns; terminology clarification from Q&A |
| 4.5 Acetylcholinesterase inhibitors | ”Classification 4: Acetylcholinesterase Inhibitors” | ~37:28–38:02 | Presentation | OPs and carbamates; not insect-specific; brief section |
| 4.6 Combination products | ”Classification 5: Combination Products” + Q&A on dual resistance | ~38:03–39:10 + ~58:25–59:00 | Both | ”Start with tea”; potentiation; confirmed dual resistance in Q&A |
| PART V: Non-Neurotoxic Insecticides | ||||
| 5.1 Diamides (calcium channels) | “Muscular Calcium Channels (Diamides)” + Q&A on earthworms | ~39:55–41:30 + ~1:01:05–1:01:40 | Both | Safety profile; contraction → depletion timeline; earthworm selectivity from Q&A |
| 5.2 Insect growth regulators | ”Insect Growth Regulators” | ~41:40–45:20 | Presentation | JH analogs + CSIs; metamorphosis types; wing twist; jackknife effect |
| 5.3 Energy production inhibitors | ”Inhibitors of Energy Production” | ~45:20–46:50 | Presentation | Mitochondria targeting; hydramethylnon, chlorfenapyr, fumigants, borates |
| 5.4 Cuticle dehydrating dusts | ”Cuticle Dehydrating Dusts” | ~47:00–48:15 | Presentation | Silica gel, DE; physical mode of action; diatom origin |
| PART VI: Practical Factors | ||||
| 6.1 Stability & formulations | ”Stability, Persistence, and Formulations” | ~48:45–51:00 | Presentation | Lipophilic nature; UV degradation; formulation types and functions |
| 6.2 Pest behavior | ”Pest Behavior” | ~51:02–53:05 | Presentation | Secondary/tertiary kill; flea larvae; trophallaxis/allogrooming |
| 6.3 Sanitation & IPM | ”Sanitation” | ~53:05–54:20 | Presentation | Food competition, clutter, grease; IPM mindset |
| 6.4 Resistance (expanded) | “Resistance” + Q&A segments | ~54:20–56:30 + multiple Q&A | Both | Rotation; cockroach bait resistance; IRAC; inevitability |
| 6.5 Oral vs. dermal toxicity | Q&A: “On Oral vs. Dermal Toxicity” | ~1:03:55–1:04:45 | Q&A only | Cuticle vs. gut barriers; mammalian skin resistance |
| 6.6 Essential oils & 25B | Q&A: “On Essential Oils and 25B Products” | ~1:05:30–1:06:40 | Q&A only | Consumer demand; repellent efficacy; registration cost advantage |
Content That Comes Exclusively from Q&A
The following material was only discussed during the Q&A exchange with Dan and would be missed if working only from the prepared presentation portion of the transcript:
| Topic | Q&A Transcript Section | Why It Matters for the Bulletin |
|---|---|---|
| Dual resistance to combo products | ”On Combination Products and Resistance” | Confirms resistance to both AIs in field populations — critical practitioner info |
| Inevitability of resistance | Same section | ”Possible always” — frames the urgency of rotation |
| New AI pipeline economics | ”On New Active Ingredients” | Urban market size limits manufacturer investment — industry context |
| IRAC as a practitioner tool | ”On IRAC Classification” | Actionable resource for product rotation decisions |
| Nicotinoid vs. neonicotinoid terminology | ”On Nicotinoids vs. Neonicotinoids” | Clears up common confusion; imidacloprid vs. clothianidin example |
| Chlorantraniliprole earthworm selectivity | ”On Chlorantraniliprole and Earthworms” | Unique selectivity even among invertebrates — safety story |
| Oral vs. dermal toxicity explanation | ”On Oral vs. Dermal Toxicity” | Foundational concept not covered in prepared talk |
| Repellent = pyrethroids, non-repellent = everything else | ”On Repellent vs. Non-Repellent Insecticides” | Clean practical distinction for practitioners |
| Essential oils / 25B market drivers | ”On Essential Oils and 25B Products” | Consumer demand and green market trends |
| Nicotine as insecticide (tobacco anecdote) | Within nicotinoid terminology discussion | Memorable historical connection |
| Scharf’s prior resistance webinar | Opening Q&A exchange | Suggests companion content exists for the resistance bulletin |
Presentation Flow vs. Bulletin Structure
The webinar followed this sequence (left), which differs from the proposed bulletin structure (right):
| Webinar Order | → | Proposed Bulletin Order |
|---|---|---|
| 1. Why MOA matters (motivation) | → | Part I: Why MOA Matters (motivation) |
| 2. Insect physiology overview | → | Part II: Insect Physiology (foundation) |
| 3. Insecticide classification basics | → | Part III: Classification Fundamentals |
| 4. LD50 concept | → | Moved into Part III (Section 3.4) |
| 5. Neurotoxic classes (5) | → | Part IV: Neurotoxic Insecticides |
| 6. Non-neurotoxic classes (4) | → | Part V: Non-Neurotoxic Insecticides |
| 7. Practical factors (stability, behavior, sanitation, resistance) | → | Part VI: Practical Factors |
| 8. Summary | → | Distributed as section conclusions |
| 9. Q&A with Dan | → | Integrated throughout relevant sections |
Key reorganization choices:
- LD50 was presented between physiology and classification; it fits better as a classification fundamental
- Combination products were discussed within neurotoxics but could also warrant their own sidebar
- Q&A content is distributed to the sections where it’s most relevant rather than kept as a standalone section
- The resistance discussion appears in both Part I (motivation) and Part VI (practical detail) — cross-reference or consolidate as preferred
Companion Documents
This source guide is part of a three-document set:
- Bulletin Draft Outline (
GTBOP_BulletinOutline_InsecticideMOA_Scharf.md) — Section-by-section content notes and writing guidance - Quick Reference Compendium (
GTBOP_ReferenceCompendium_InsecticideMOA_Scharf.md) — Consolidated tables of all classifications, products, and relationships - This Source Guide (
GTBOP_SourceGuide_InsecticideMOA_Scharf.md) — Transcript location mapping
All three draw exclusively from the same source: the corrected and verified prose transcript of Dr. Scharf’s October 18, 2017 GTBOP presentation.
Prepared from GTBOP webinar archive materials for UGA Center for Urban Agriculture.